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  • Andreas Rummel, Stefan Mahrhold, Hans Bigalke, Thomas Binz
  • Biology, Medicine
  • Molecular microbiology
  • 2004 (First Publication: 15 December 2003)
  • Tetanus and botulinum neurotoxins selectively invade neurons following binding to complex gangliosides. Recent biochemical experiments demonstrate that two ganglioside binding sites within theContinue Reading
  • Andreas Rummel, Timo Eichner, +8 authors Thomas Binz
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2007 (First Publication: 2 January 2007)
  • Botulinum neurotoxins (BoNTs) cause muscle paralysis by selectively cleaving core components of the vesicular fusion machinery within motoneurons. Complex gangliosides initially bind into a pocketContinue Reading
  • Andreas Rummel, Kirstin Häfner, +7 authors Thomas Binz
  • Biology, Medicine
  • Journal of neurochemistry
  • 2009 (First Publication: 1 September 2009)
  • The high toxicity of clostridial neurotoxins primarily results from their specific binding and uptake into neurons. At motor neurons, the seven botulinum neurotoxin serotypes A-G (BoNT/A-G) inhibitContinue Reading