Stefan Kraemer

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Design tools for application specific instruction set processors (ASIPs) are an important discipline in systems-level design for wireless communications and other embedded application areas. Some ASIPs are still designed completely from scratch to meet extreme efficiency demands. However, there is also a trend, towards use of partially predefined,(More)
With the growing number of programmable processing elements in today's <i>Multi Processor System-on-Chip</i> (MPSoC) designs, the synergy required for the development of the hardware architecture and the software running on them is also increasing. In MPSoC development environment, changes in the hardware architecture can bring in extensive re-partitioning(More)
Current Application Specific Instruction set Processor (ASIP) design methodologies are mostly based on iterative architecture exploration that uses Architecture Description Languages (ADLs) and retargetable software development tools. However, for improved design efficiency, additional pre-architecture exploration tools are required to help narrow-down the(More)
Interleukin (IL) 2-deficient mice develop a fatal immunopathology characterized by lymphoadenopathy, splenomegaly, T cell infiltration of the bone marrow, loss of B cells, anemia, and inflammation of the gut. The thymus dependence of these disease symptoms was tested by introducing the IL-2 mutation into athymic mice. With the exception of an increase in(More)
The increasing complexities of today’s embedded multimedia and wireless devices have ushered in the era of heterogeneous MultiProcessor System-on-Chip (MPSoC) architectures. This trend, in turn, have made software parallelization and optimization a subject of utmost importance for today’s systems. Nowadays, providing efficient software implementations is(More)
The requirement for interleukin-2 (IL-2) in repertoire selection and peripheral activation of CD8 T cells was tested in mice rendered IL-2 deficient by gene targeting and expressing a transgenic T cell receptor (TcR) (F5) specific for influenza nucleoprotein (NP) 366-374 + H-2Db. Positive selection of the transgenic F5 TcR into the CD8 compartment proceeded(More)
The mAb R73 directed to the TCR-alpha/beta of rat lymphocytes was tested for its therapeutic potential during the effector phase of experimental autoimmune neuritis (EAN) in Lewis rats. EAN can be actively induced by immunization with bovine peripheral nerve myelin, bovine P2 protein, or a peptide containing its neuritogenic epitope and serves as a model of(More)
Instruction Set Simulation (ISS) is widely used in system evaluation and software development for embedded processors. Despite the significant advancements in the ISS technology, it still suffers from low simulation speed compared to real hardware. Especially for embedded software developers simulation speed close to real time is important in order to(More)
<i>Instruction Set Simulators</i> (ISSes) are important tools for cross-platform software development. The simulation speed is a major concern and many approaches have been proposed to improve the performance of ISSes. A prevalent technique is compiled simulation, which translates target programs into host instructions. But orders of magnitude of speed(More)