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Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. We compared the structure and function of the CXXC domains in the DNA methyltransferase Dnmt1 and the methylcytosine dioxygenase Tet1. Sequence alignment showed that both CXXC domains have a very similar framework but differ in the central tip region.(More)
Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia formation, but the underlying mechanisms remain elusive. In this study, we investigate the uncharacterized gene Flattop (Fltp) that is transcriptionally activated during PCP acquisition in ciliated tissues. Fltp knock-out mice show BB docking and ciliogenesis defects(More)
Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for cancer treatment failure. Here, we undertook a high content(More)
Während der Embryonalentwicklung entsteht das Entoderm, aus dem sich unter anderem Lunge, Pankreas und Darm ableiten. Die Erforschung der Mechanismen und Gene, die diese Prozesse steuern, ist wichtig für das Verständnis einer Vielzahl von Krankheiten. During embryonic development the endoderm gives rise to organs such as lung, pancreas and intestine. The(More)
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