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  • Norbert Prenzel, Oliver Martin Fischer, Sylvia Streit, Stefan Hart, Axel Ullrich
  • Medicine, Biology
  • Endocrine-related cancer
  • 2001 (First Publication: 1 March 2001)
  • Homeostasis of multicellular organisms is critically dependent on the correct interpretation of the plethora of signals which cells are exposed to during their lifespan. Various soluble factorsExpand
  • Anthony William, Angeline Lee, +16 authors Brian W Dymock
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2011 (First Publication: 15 June 2011)
  • Discovery of the activating mutation V617F in Janus Kinase 2 (JAK2(V617F)), a tyrosine kinase critically involved in receptor signaling, recently ignited interest in JAK2 inhibitor therapy as aExpand
  • Anders Poulsen, Harish Nagaraj, +8 authors Meredith Williams
  • Chemistry, Medicine, Computer Science
  • J. Chem. Inf. Model.
  • 2014 (First Publication: 23 October 2014)
  • Phosphoinositide 3-kinases (PI3Ks) and the mammalian target of rapamycin (mTOR) act as critical effectors in a commonly deregulated cell signaling pathway in human cancers. The abnormal activation ofExpand
  • Anthony William, Angeline Lee, +14 authors Brian W Dymock
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2012 (First Publication: 6 March 2012)
  • Herein, we describe the synthesis and SAR of a series of small molecule macrocycles that selectively inhibit JAK2 kinase within the JAK family and FLT3 kinase. Following a multiparameter optimizationExpand