Stefan Hader

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
Here we describe the successful syntheses of a series of 4-, 7-, 8- and 9-deoxygenated 2,3-difluoro-N-acetylneuraminic acid derivatives as potential mechanism-based inhibitors of sialidases. The syntheses commenced utilising an enzyme-catalysed aldolase reaction between N-acetyl mannosamine and β-fluoropyruvic acid to give 3-fluoro-N-acetyl-neuraminic acid.(More)
Copyright Statement This research was originally published in Journal of Biological Chemistry (JBC). Judith C. Telford, Juliana H.F. Yeung, Guogang Xu, Milton J. Kiefel, Andrew G. Watts, Stefan Hader, Jefferson Chan, Andrew J. Bennet, Margo M. Moore and Garry L. Taylor,The Aspergillus fumigatus Sialidase Is a 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid(More)
Aspergillus fumigatus is a filamentous fungus that can cause severe respiratory disease in immunocompromised individuals. A putative sialidase from A. fumigatus was recently cloned and shown to be relatively poor in cleaving N-acetylneuraminic acid (Neu5Ac) in comparison with bacterial sialidases. Here we present the first crystal structure of a fungal(More)
  • 1