Stefan Girke

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The activity of cationic amphiphilic compounds to affect artificial phospholipid-membranes was compared with the membrane-stabilizing cardiodepressant potency of the drugs. The twenty-one investigated catamphiphilic compounds belonged to various pharmacological groups including antiarrhythmic, local anaesthetic, beta-blocking, antimalarial, and psychoactive(More)
BACKGROUND Chronic severe pulmonary regurgitation (PR) causes progressive right ventricular (RV) dysfunction and heart failure. Parameters defining the optimal time point for surgery of chronic PR are lacking. The present study prospectively evaluated the impact of preoperative clinical parameters, cardiorespiratory function, QRS duration and NT-proBNP(More)
This thesis investigates efficient schemes for parameterized multiscale problems. The reduced basis method is a well-known technique for the reduction of computational effort for parameterized partial differential equations. Herein two extensions of the methodology are introduced. First, an extension to problems with high parameter dimension is suggested.(More)
The compact Discontinuous Galerkin 2 (CDG2) method was successfully tested for elliptic problems, scalar convection-diffusion equations and compressible Navier-Stokes equations. In this paper we use the newly developed DG method to solve a mathematical model for early stages of atherosclerotic plaque formation. Atherosclerotic plaque is mainly formed by(More)
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