Stefan Gattenlohner

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M Mohty, H de Lavallade, J El-Cheikh, P Ladaique, C Faucher, S Fürst, N Vey, D Coso, A-M Stoppa, J-A Gastaut, C Chabannon and D Blaise Unité de Transplantation et de Thérapie Cellulaire (UTTC), Institut Paoli-Calmettes, Marseille, France; Departement d’Hématologie, Institut Paoli-Calmettes, Marseille, France; Faculté de Médecine, Université de la(More)
We sought to develop an accurate colorectal cancer model in nude mice with stable local growth, tumor cell dissemination, and reproducible metastatic capacity. To this end, we orthotopically transplanted histologically intact human colorectal cancer tissue from 10 human patients into nude mice. After successful local tumor growth, tumor tissues were(More)
BACKGROUND The development of therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models generating both metastases and the dissemination of tumor cells. METHODS To prove the efficiency of orthotopic implantation concerning induction of minimal residual disease (MRD) colorectal(More)
S Park, D Borderie, C Cormier, D Bouscary, C Roux, C Job-Deslandre, A Merlat, B Cherreau, JC Souberbielle and F Dreyfus Service d’hématologie, Cochin Hospital, APHP, Paris, France; Services de rhumatologie, Cochin Hospital, APHP, Paris, France; Laboratoire de biochimie A, Cochin Hospital, APHP, Paris, France and Novartis Pharma S.A.S, BU oncologie, Rueil(More)
reduction in wild-type TP53 or ATM below a critical level. The important practical question is whether this functional assay provides additional prognostic information compared to standard fluorescence in situ hybridization analysis for TP53 and ATM loss. Seven out of 47 patients in this study had TP53 dysfunction and either an ATM or TP53 mutation without(More)
The development of new therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models that generate both reproducible metastasis and the dissemination of tumor cells in the form of so-called minimal residual disease (MRD), an expression of the systemic character of neoplastic disease. We(More)
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