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The transcription factor c-Maf controls touch receptor development and function.

• Hagen Wende, Stefan G. Lechner, +8 authors Carmen Birchmeier
• Science
• 2012

The sense of touch relies on detection of mechanical stimuli by specialized mechanosensory neurons. The scarcity of molecular data has made it difficult to analyze development of mechanoreceptors and… (More)

The Molecular and Cellular Identity of Peripheral Osmoreceptors

• Stefan G. Lechner, Sören Markworth, +10 authors Gary R Lewin
• Neuron
• 2011

In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic… (More)

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development

• Stefan G. Lechner, Henning Frenzel, Rui Wang, Gary R Lewin
• The EMBO journal
• 2009

Somatic sensation relies on the transduction of physical stimuli into electrical signals by sensory neurons of the dorsal root ganglia. Little is known about how and when during development different… (More)

The molecular basis of acid insensitivity in the African naked mole-rat.

• Ewan St John Smith, Damir Omerbašić, Stefan G. Lechner, Gireesh Anirudhan, Liudmila Lapatsina, Gary R Lewin
• Science
• 2011

Acid evokes pain by exciting nociceptors; the acid sensors are proton-gated ion channels that depolarize neurons. The naked mole-rat (Heterocephalus glaber) is exceptional in its acid insensitivity,… (More)

Peripheral sensitisation of nociceptors via G-proteindependent potentiation of mechanotransduction currents

• Stefan G. Lechner, Gary R Lewin
• The Journal of physiology
• 2009

Mechanical stimuli impinging on the skin are converted into electrical signals by mechanically gated ion channels located at the peripheral nerve endings of dorsal root ganglion (DRG) neurons. Under… (More)

Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.

• Stefan G. Lechner, Mario M Dorostkar, Martina Mayer, Hannah Edelbauer, Halyna Pankevych, Stefan Boehm
• The European journal of neuroscience
• 2004

Although feedback inhibition of noradrenaline release by coreleased nucleotides is a well known phenomenon, it remained unclear which P2 receptor subtypes and associated signalling cascades may be… (More)

Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels.

• Stefan G. Lechner, Martina Mayer, Stefan Boehm
• The Journal of physiology
• 2003

Acetylcholine has long been known to excite sympathetic neurons via M1 muscarinic receptors through an inhibition of M-currents. Nevertheless, it remained controversial whether activation of… (More)

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

• Alice Arcourt, Louise C J Gorham, +7 authors Stefan G. Lechner
• Neuron
• 2017

Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we… (More)

Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy

• Gary R Lewin, Stefan G. Lechner, Ewan St John Smith
• Handbook of experimental pharmacology
• 2014

Nerve growth factor (NGF) is central to the development and functional regulation of sensory neurons that signal the first events that lead to pain. These sensory neurons, called nociceptors, require… (More)

Presynaptic inhibition via a phospholipase C- and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels.

• Stefan G. Lechner, Simon Hussl, Klaus W. Schicker, Helmut Drobny, Stefan Boehm
• Molecular pharmacology
• 2005

Presynaptic inhibition of transmitter release is commonly mediated by a direct interaction between G protein betagamma subunits and voltage-activated Ca2+ channels. To search for an alternative… (More)

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