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miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis. It is not yet clear whether miRNAs are able to regulate mitochondrial fission. Here we report that miR-30 family members are able to regulate(More)
WaLBerla (Widely applicable Lattice-Boltzmann from Erlangen) is a massively parallel software framework supporting a wide range of physical phenomena. This article describes the software designs realizing the major goal of the framework, a good balance between expandabil-ity and scalable, highly optimized, hardware-dependent, special purpose kernels. To(More)
SUMMARY Mineral nitrogen (N) fertilization in cereals is commonly split into three or four applications. In order to simplify N fertilization, a single N application either broadcast or placed on the soil surface was compared to conventionally split fertilization for winter wheat (Triticum aestivum L.). The 4-year experiment (2007–2010) was performed using(More)
BACKGROUND Ischemic heart disease and heart failure are associated with an increased loss of cardiomyocytes due to apoptosis. Whether cardiomyocyte apoptosis plays a causal role in the pathogenesis of heart failure remains enigmatic. The apoptosis repressor with caspase recruitment domain (ARC) is a recently discovered antiapoptotic factor with a highly(More)
Despite its complexity of action, doxorubicin (Dox)-induced cardiomyopathy eventually results in loss of cardiac myocytes which further contributes to the development of overt heart failure. In the present study, we examined the relevance of the apoptosis repressor with caspase recruitment domain (ARC) on cardiac myocyte survival and its underlying(More)
BACKGROUND & AIMS Acetaminophen (AAP) overdose is the most frequent cause of drug-induced liver failure. c-Jun N-terminal kinase (JNK) is thought to play a central role in AAP-induced hepatocellular necrosis. The apoptosis repressor with caspase recruitment domain (ARC) is a death repressor that inhibits death receptor and mitochondrial apoptotic signaling.(More)