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  • Stefan Düsterhöft, Sascha Jung, +4 authors Inken Lorenzen
  • Medicine, Chemistry
  • Journal of the American Chemical Society
  • 2013 (First Publication: 17 April 2013)
  • A disintegrin and metalloprotease-17 (ADAM17) is a major sheddase responsible for the regulation of a wide range of biological processes, like cellular differentiation, regeneration, or cancerContinue Reading
  • Stefan Düsterhöft, Katharina Hoebel, +8 authors Joachim Groetzinger
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2014 (First Publication: 30 April 2014)
  • Background: A disintegrin and metalloprotease 17 (ADAM17) releases many proinflammatory mediators. Results: The conserved ADAM seventeen dynamic interaction sequence (CANDIS) mediates effectiveContinue Reading
  • Joachim Groetzinger, Inken Lorenzen, Stefan Düsterhöft
  • Medicine, Biology
  • Biochimica et biophysica acta. Molecular cell…
  • 2017 (First Publication: 1 November 2017)
  • In contrast to many other signalling mechanisms shedding of membrane-anchored proteins is an irreversible process. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major sheddases involvedContinue Reading
  • Inken Lorenzen, Juliane Lokau, +5 authors Joachim Groetzinger
  • Biology, Medicine
  • FEBS letters
  • 2012 (First Publication: 24 April 2012)
  • A great number of physiological processes are regulated by the release of ectodomains of membrane proteins. A Disintegrin And Metalloprotease 17 (ADAM17) is one of the important enzymes, whichContinue Reading