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Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant(More)
Biological function relies on the fact that biomolecules can switch between different conformations and aggregation states. Such transitions involve a rearrangement of parts of the biomolecules involved that act as dynamic domains. The reliable identification of such domains is thus a key problem in biophysics. In this work we present a method to identify(More)
Phosphorescent iridium(III) complexes are being widely explored for their utility in diverse photophysical applications. The performance of these materials in such roles depends heavily on their excited-state properties, which can be tuned through ligand and substituent effects. This concept article focuses on methods for synthetically tailoring the(More)
A method for accelerating the discovery of ionic luminophores using combinatorial techniques is reported. The photophysical properties of the resulting transition-metal-based chromophores were compared against a series of analogous, traditionally prepared species. The strong overlap between these two sets confirms the identity of the parallel synthesis(More)
Photolysis of water, a long-studied strategy for storing solar energy, involves two half-reactions: the reduction of protons to dihydrogen and the oxidation of water to dioxygen. Proton reduction is well-understood, with catalysts achieving quantum yields of 34% when driven by visible light. Water oxidation, on the other hand, is much less advanced,(More)
Protons from water are reduced by a catalytic system composed of a heteroleptic iridium(III) photosensitizer [Ir(ppy)2(bpy)]+, platinum catalyst, and sacrificial reductant. The hydrogen quantum yield reaches 0.26 in this study, which proceeds via reductive quenching of the excited photosensitizer by triethanolamine. This simplified approach allows the(More)
A series of bis-phenylpyridine, bis-aquo iridium(III) complexes is herein shown to robustly and efficiently catalyze the oxidation of water to dioxygen in the presence of a sacrificial oxidant. Through substitution on the cyclometalating ligands of these complexes, it is shown that a broad range of oxidation potentials can be achieved within this class of(More)
BACKGROUND The pressure drop-flow relations in myocardial bridges and the assessment of vascular heart disease via fractional flow reserve (FFR) have motivated many researchers the last decades. The aim of this study is to simulate several clinical conditions present in myocardial bridges to determine the flow reserve and consequently the clinical relevance(More)
We report on the spectroscopic, electrochemical, and electroluminescent properties of [Ir(ppy)(2)(dtb-bpy)](+)(PF(6))(-) (ppy: 2-phenylpyridine, dtb-bpy: 4,4'-di-tert-butyl-2,2'-dipyridyl). Single-layer devices were fabricated and found to emit yellow light with a brightness that exceeds 300 cd/m(2) and a luminous power efficiency that exceeds 10 Lm/W at(More)
Transition metal complexes have emerged as promising candidates for applications in solid-state electroluminescent devices. These materials serve as multifunctional chromophores, into which electrons and holes can be injected, migrate and recombine to produce light emission. Their device characteristics are dominated by the presence of mobile ions that(More)