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The adrenal hormone corticosterone transcriptionally regulates responsive genes in the rodent hippocampus through nuclear mineralocorticoid and glucocorticoid receptors. Via this genomic pathway the hormone alters properties of hippocampal cells slowly and for a prolonged period. Here we report that corticosterone also rapidly and reversibly changes(More)
We present the design and implementation of a system that enables trusted computing for an unlimited number of virtual machines on a single hardware platform. To this end, we virtualized the Trusted Platform Module (TPM). As a result, the TPM's secure storage and cryptographic functions are available to operating systems and applications running in virtual(More)
Corticosteroid action in the brain is mediated by the mineralocorticoid (MR) and the glucocorticoid (GR) receptor. Disturbances in MR- and GR-mediated effects are thought to impair cognition, behavior, and endocrine control. To assess the function of the limbic MR in these processes, we inactivated the MR gene in the forebrain of the mouse using the(More)
We present the sHype hypervisor security architecture and examine in detail its mandatory access control facilities. While existing hypervisor security approaches aiming at high assurance have been proven useful for high-security environments that prioritize security over performance and code reuse, our approach aims at commercial security where near-zero(More)
High levels of corticosteroids (as circulate after stress) quickly and reversibly enhance hippocampal glutamatergic transmission via nongenomic actions requiring mineralocorticoid receptors. Subsequently, the hormone slowly and long-lastingly normalizes hippocampal cell function, through nuclear glucocorticoid receptors. Here we describe a rapid(More)
Virtualization technology is becoming increasingly common in datacenters, since it allows for collocation of multiple workloads, consisting of operating systems, middleware and applications, in different virtual machines (VMs) on shared physical hardware platforms. However, when coupled with the ease of VM migration, this trend increases the potential(More)
In this paper we present our experience in building the Research Compute Cloud (RC2), a cloud computing platform for use by the worldwide IBM Research community. Within eleven months of its official release RC2 has reached a community of 631 users spanning 34 countries , and serves on average 350 active users and 1800 active VM instances per month. Besides(More)
We consider a wireless ad-hoc network with single antenna nodes under a two-hop traffic pattern. Two system architectures are investigated in this paper: Either linear amplify-and-forward relays (LinRel) or a distributed antenna system with linear processing (LDAS) serve as repeater nodes. The gain factors of the repeaters are assigned such that the mean(More)
BACKGROUND The analysis of the role of genes in important brain functions like learning, memory and synaptic plasticity requires gene inactivation at the adult stage to exclude developmental effects, adaptive changes or even lethality. In order to achieve temporally controlled somatic mutagenesis, the Cre/loxP-recombination system has been complemented with(More)
The trusted virtual data center (TVDc) is a technology developed to address the need for strong isolation and integrity guarantees in virtualized environments. In this paper, we extend previous work on the TVDc by implementing controlled access to networked storage based on security labels and by implementing management prototypes that demonstrate the(More)