Stefan Antohi

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At lower concentrations, polyarginine, polylysine, protamine, histones H1, H2A, H2B and H3 cause lysis of human erythrocytes, whereas at higher concentrations inner histones are not hemolytic but induce only surface condensation and alterations in the cell-shape. Antibody coated erythrocytes treated with polyarginine result in ghost-like spheres having(More)
Under experimental conditions of genetic transformation, protamine and total histone were bactericidal for Bacillus subtilis cells. The abilities to cause lethality were very similar for both, either protamine or histone, with no antagonistic effects amongst these natural polycations. With both basic proteins acting simultaneously the enhancement was higher(More)
According to the model of plasma membrane compartmentation into functional endocytosis-exocytosis units it is suggested that the respective compartments may also take part in the receptor mediated internalization of viruses. The primary effect of myxo- and paramyxovirus invasion would consist in the intercalation of new microzones in the recycling of the(More)
The genetic diversity of viruses and the genetic constitution (polygenic configuration) of susceptible organisms participate together in the determination of a virus disease and of its clinical forms. Genes of sensitivity to viral infection, genes of nonspecific defense (encoding for interferons, complement factors), immune response regulating genes and(More)
Poly-L-arginine, Protamine, Bacillus subtilis, Staphylococcus aureus, Glutaraldehyde Pretreatments of B. subtilis and S. aureus cells with lower concentrations of fixative agents, led to modifications in bacteriolytic effect exerted by polyarginine and protamine: Glutaraldehyde blocked polycation bacteriolysis while formaldehyde and osmium tetroxide (0 s0(More)
The effect of a polycation (histone H2A) and of oligocations (spermine, spermidine and putrescine) on Sendai and influenza virus particles was investigated by light scattering measurements at 90 degrees and at various wavelengths. The method allows the study of the changes in the size and shape of virus particles in suspension.
As evaluated by light scattering at 90 degrees, natural organic oligocations such as putrescine, spermidine and spermine interfered with myxovirus aggregates which were induced by the histone H2A and strongly amplified by shaking during incubation. In contrast, the synthetic oligocation 1.7-diamino heptane itself aggregated the virus particles, its action(More)