Stefan Andersson

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The goal of the DiVA project is to develop a workflow where information from the original document created by the author can be reused to extract metadata for various purposes. There are two ways to submit an item and store the metadata in the SYSTEM: 1. using a template (MS Word, Open Office, Star Office, LaTeX) 2. updating through the DiVA Manager(More)
The type 2 isoform of human 17␤-hydroxysteroid dehydrogenase (17␤HSD2) efficiently catalyzes the oxidative metabolism of andro-gens and estrogens, and it is expressed in a large series of human peripheral tissues. To obtain a better understanding of the regulation of local steroid biosynthesis and metabolism in human tissues, we have established a dual(More)
The mechanism of inhibition of the rat types 1 and 2 5alpha-reductase by finasteride was investigated using recombinantly expressed enzymes. These studies revealed that finasteride is a potent, reversible inhibitor of the rat type 1 5alpha-reductase with Ki=10.2+/-1.3 nM. Finasteride is a potent inhibitor of the rat type 2; however, in this case the(More)
Cholesterol 24-hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the majority of cholesterol turnover in the central nervous system. Mice deficient in 24-hydroxylase exhibit impaired learning and defective hippocampal long-term potentiation, suggesting that the metabolism of cholesterol by this(More)
One of the objectives of the DiVA project is to explore the possibility of using XML as a format for long-term preservation. For this reason , the practical use of XML in different parts of the SYSTEM was evaluated before deciding on the design. The DiVA Document Format-defined by an XML schema-has been developed to describe the interrelationships amongst(More)
1 Restricted – Confidential Information Access to and distribution of this document is restricted to the persons listed under the heading Circulation Restricted. This document is confidential to the Association and is subject to copyright protection. This document is to be used only for the purposes for which it has been supplied and information contained(More)
Aldosterone is the principal endogenous mineralocorticoid in humans and regulates salt and water homeostasis. Cortisol, the major glucocorticoid, has high affinity for the mineralocorticoid receptor; however, 11beta-hydroxysteroid dehydrogenase type 2 converts cortisol to the inactive steroid cortisone in aldosterone target cells of the kidney, thus(More)