Learn More
BACKGROUND & AIMS Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sustained stellate cell activation for(More)
BACKGROUND Scarring of the liver is the result of prolonged exposure to exogenous or endogenous stimuli. At the onset of fibrosis, quiescent hepatic stellate cells (HSCs) activate and transdifferentiate into matrix producing, myofibroblast-like cells. AIM AND METHODS To identify key players during early HSC activation, gene expression profiling was(More)
BACKGROUND & AIMS Cancer stem cells (CSCs) are thought to be persistent in tumours due to their chemoresistance and to cause relapse and metastasis. Hepatic carcinomas displaying hepatic progenitor cell (HPC) features have been associated with a poor prognosis, though it remains unclear how CSCs relate to these different histological subtypes. METHODS(More)
BACKGROUND The gap between the demand and supply of organs has prompted examination of health care professionals' roles in organ retrieval. This study examines Illinois family physicians' advisory roles as reflected in their beliefs and conversations with patients about cadaveric organ donation. METHODS A 50-item questionnaire was mailed to a random(More)
The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are believed to arise also from a facultative(More)
SCOPE Virtually all chronic liver injuries result in the activation of hepatic stellate cells (HSCs). In their activated state, these cells are the main collagen-producing cells implicated in liver fibrosis. Capsaicin (CPS), the active compound of chili peppers, can modulate the activation and migration of HSCs in vitro. Here, we evaluated the potential(More)
Globalisation, liberalisation and convergence of communication markets have triggered intensive debates about the options for regulatory reform, including the growing role of alternative modes of regulation (self-regulation, co-regulation). These alternatives or supplements to traditional statutory regulation are marked by the involvement of nongovernmental(More)
ACKNOWLEDGMENTS We greatly appreciate the financial support from the Texas Department of Transportation that made this project possible. The support of the Project Director, Jon Kilgore, (SAT) and Project Coordinator, W. Cox, (BRG) is also very much appreciated. We would also like to thank monitoring committee members, R. Baker (LBB), David McDonnold (BRG),(More)