Steen Lindkær Jensen

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Certain neurochemical and connectional characteristics common to extended amygdala and the nucleus accumbens shell suggest that the two represent a single functional-anatomical continuum. If this is so, it follows that the outputs of the two structures should be substantially similar. To address this, projections from the caudomedial shell and central(More)
We studied the epidemiology of ankle fractures prospectively during 1 year in a population of about 200,000. The overall incidence rate was 107 fractures per 10(5) person-years. Below the age of 50, ankle fractures were commonest in men. After this age, females became predominant and the age-specific incidence rates decreased in both sexes. The main cause(More)
Proliferation-linked expression of the nuclear Ki-S1 antigen is a significant prognostic indicator in mammary carcinomas. Here, we show staining of a protein of 170 kd by Ki-S1 antibody in immunoblots of Saccharomyces cerevisiae expressing human topoisomerase II alpha but not in the parental strain. In HL-60 cells containing both isoforms of human(More)
OBJECTIVE To investigate if double gloving can reduce the rate of perforation of glove barriers during abdominal surgery. DESIGN Randomised controlled trial. SETTING County hospital, Denmark. SUBJECTS 400 glove barriers from principal surgeons and first assistants used at consecutive abdominal operations. INTERVENTION Each participant was randomised(More)
Interleukin 10 (IL-10) is a recently described natural endogenous immunosuppressive cytokine that has been identified in human, murine, and other organisms. Human IL-10 (hIL-10) has high homology with murine IL-10 (mIL-10) as well as with an Epstein-Barr virus genome product BCRFI. This viral IL-10 (vIL-10) shares a number of activities with hIL-10. IL-10(More)
In pancreatic islets a peptide corresponding to the C-terminal tetrapeptide amide of cholecystokinin and gastrin, Trp-Met-Asp-Phe-NH2, is present in nerve terminals. This tetrapeptide amide is uniquely potent as a releaser of insulin and the other islet hormones, whereas larger cholecystokinins and gastrins as well as tetrapeptide analogues are considerably(More)
THE EFFECT OF EFFERENT, PARASYMPATHETIC STIMULATION UPON PANCREATIC POLYPEPTIDE (PP) SECRETION WAS STUDIED IN THREE WAYS: (a) Plasma PP concentrations increased in response to insulin-induced hypoglycemia in both normal subjects, from 11 pM (9.5-12.5) to 136 pM (118-147), n = 8 (median and interquartile range) and in duodenal ulcer patients, from 33 pM(More)
BACKGROUND Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. AIMS To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbit model of severe acute pancreatitis.(More)
BACKGROUND Disturbances of coagulation and fibrinolysis are well-known systemic effects of acute necrotising pancreatitis (ANP). The purpose of this experimental study was to evaluate the initial events in the haemostatic activation during ANP in an animal model with relevance to the human situation. METHODS ANP was introduced in 7 rabbits by infusion of(More)