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We consider the problem of the global convergence of gradient-based optimization algorithms for interstitial high-dose-rate (HDR) brachytherapy dose optimization using variance-based objectives. Possible local minima could lead to only sub-optimal solutions. We perform a configuration space analysis using a representative set of the entire non-dominated… (More)

OBJECTIVE
To determine the clinical aspects and evolution of autoimmune inflammatory manifestations (AIMs) in patients with myelodysplastic syndrome (MDS) and ascertain the prognostic implications of these manifestations in MDS.
METHODS
Seventy patients diagnosed for MDS were enrolled in a prospective cohort study of 4-yr duration. Thirteen patients with… (More)

We have studied the accuracy of statistical parameters of dose distributions in brachytherapy using actual clinical implants. These include the mean, minimum and maximum dose values and the variance of the dose distribution inside the PTV (planning target volume), and on the surface of the PTV. These properties have been studied as a function of the number… (More)

This paper describes innovative software for automatic reconstruction, which we term autoreconstruction, of plastic and metallic brachytherapy catheters using computed tomography (CT) data. No such automatic facility has previously existed in any treatment planning software. The patient data consists of a set of post-implantation CT images with the… (More)

The aim of our study was to develop an algorithm to simulate the digitally reconstructed radiograph (DRR) calculation process for different beam qualities (photon energies) in the range 50 keV to 12 MeV. This was achieved using volumetric anatomical data for the patient obtained from three-dimensional diagnostic CT images. These DRR images can be used in… (More)

- S Giannouli, D Baltas, N Milickovic, M Lahanas, C Kolotas, N Zamboglou +1 other
- Medical physics
- 2000

The most accurate classical dose optimization algorithms in HDR brachytherapy strongly depend on an appropriate selection of source dwell positions which fulfill user-defined geometrical boundary conditions which are relative to patient anatomy. Most anatomical situations, such as for prostate and head and neck tumors, are complex and can require geometries… (More)

We consider the inverse planning problem in brachytherapy, i.e. the problem to determine an optimal number of catheters, number of sources for low-dose rate brachytherapy (LDR) and the optimal dwell times for high-dose rate brachytherapy (HDR) necessary to obtain an optimal as possible dose distribution. Starting from the 1930s, inverse planning for LDR… (More)

A stratified sampling method for the efficient repeated computation of dose-volume histograms (DVHs) in brachytherapy is presented as used for anatomy based brachytherapy optimization methods. The aim of the method is to reduce the number of sampling points required for the calculation of DVHs for the body and the PTV. From the DVHs are derived the… (More)

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