Stavros Michael

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OBJECTIVES to determine whether ursodeoxycholic acid (UDCA) is effective in improving primary biliary cirrhosis (PBC) or chronic hepatitis (CH). METHODS Meta-analysis (MA) was performed on nine papers and three abstracts describing PBC and on nine papers and two abstracts with CH that were published between 1985 and 1992 and were identified through(More)
Recent series reported successful autologous bonemarrowderived mesenchymal stromal cells transplantation in 10 patients with fistulising Crohn's disease (CD).1 We wish to provide a relative experience on the long-term successful autologous haematopoietic stemcell transplantation (HSCT) in a patient with refractory CD who has completed a 31-month follow up.(More)
To determine the effectiveness of vigorous realimentation with dietary fat, 17 subjects aged 64.0 +/- 2.1 years (mean +/- 1 SEM) were pump-fed via a nasogastric tube for an average of 22 days. The diet was liquid and nutritionally complete, high in unsaturated fat (67% of energy) and in the caloric density (12.6 kJ/mL or 3 Kcal/mL) [corrected]. Advanced(More)
Bile acids, in a random sample of urine, discriminated normal controls from liver disease, with a probability similar to fasting plasma bile acids (p less than 0.01 and p less than 0.001, depending on the analytical technique). A high degree of correlation between urinary and plasma bile acids (up to r = 0.93) was achieved only when the urine flow was(More)
BACKGROUND/AIMS We performed this study in order to evaluate the diagnostic potential of bile acids in random samples of urine for detection of latent liver disease and to compare a radioimmunoassay for urine bile acids with an enzymatic method that detects bile acid sulfates. This was a prospective cohort study carried out at the VA Medical Center(More)
BACKGROUND Benefits of ursodeoxycholic acid (UDCA) in cholestatic disorders have been well documented. However, the therapeutic potential of UDCA in parenchymal liver disease is unclear. METHODS We tested UDCA in rat models of hepatotoxicity: (a) in subacute liver injury induced by repetitive CCl4 and dietary ethyl alcohol (ETH) over seven weeks while(More)
Considering the well-documented protection of acetylcysteine (AC) in hepatotoxicity related to acetaminophen, we studied the preventive potential of AC against mild hepatotoxicity of CCl4, potentiated with ethyl alcohol (ETH) and the role of tissue glutathione. Rats fed a liquid diet with 30% of energy from ETH, had-intraperitoneal CCl4 administered in(More)