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Morphological alterations of mitochondria may be related to metabolic and energy deficiency in neurons in Alzheimer's disease and other neurodegenerative disorders. Mitochondrial dysfunction is also a hallmark of beta peptide induced neuronal toxicity in Alzheimer's disease. A general change in glucose utilization, increased oxidative stress, and Ca;{2+}(More)
The cellular morphology and the three dimensional cytoarchitecture of layer I of the adult human acoustic cortex were studied by using sagittal, transverse and tangential Golgi preparations and electron microscopy. The prominent neuron of layer I of the acoustic cortex is the Retzius-Cajal cell which is a solitary neuron accompanied by satellite astrocytes(More)
Alzheimer's disease is one of the main causes of cognitive impairment in the presenium and senium. Despite increased efforts in investigations of the aetiological background of the disease, most of the pathogenetic mechanisms remain unclear. From the morphological point of view, neurofibrillary degeneration and neuritic plaques, the main hallmarks of(More)
Alzheimer's disease is the most common cause of irreversible dementia, affecting mostly the presenile and senile age, shaping a tragic profile in the epilogue of the life of the suffering people. Due to the severity and the social impact of the disease an ongoing research activity is in climax nowadays, associated with many legal, social, ethical,(More)
Kimmerle's anomaly also known as ponticulus posticus is a common anatomical variation of the atlas, the first cervical vertebra. It is the product of the complete or incomplete ossification of the posterior atlanto-occipital membrane over the vertebral artery groove resulting in the formation of a foramen (arcuate foramen) containing the vertebral artery(More)
Cerebellum explants from 15--16 day fetal mice were irradiated with 500--1000 rad X-ray and were grown in tissue culture for 12--18 days. At the dose of 500 rad, a reduction of granule cell population was observed in the explant. At the dose of 1000 rad, granule cells were mostly destroyed leaving Purkinje cells disarrayed and clustered. Electron microscopy(More)
Morphological studies were made of human acoustic cortex by light and electron microscopy. The synapses of the cortical neurons were described and their morphology was correlated with the morphology of the neurons on each cortical layer. Most of the synapses are triangular, disc-like, ovoid fusiform or mushroom-shaped. Complex-shaped perforated synapses(More)
Biopsiematerial aus den Stimmuskeln von Patienten, die an einer Steinertschen Myodystrophie, einer Myodystrophie von Duchenne, einer progressiven occulopharyngealen Myodystrophie oder einer paraneoplastischen Myopathie litten, wurde licht- und elektronenmikroskopisch untersucht. Die histologischen Befunde sind mit den Veränderungen vergleichbar, die auch an(More)
The role of chronic inflammation in the pathogenesis of Alzheimer's disease (AD) has been implied in a plethora of studies. The objective of the present study was to evaluate the immune alterations and the immunological markers in patients suffering from AD. IL-1alpha, IL-2, IL-6, IL-8, IL-10, TNF-alpha cytokine and helper/inducer (CD4),(More)