OBJECTIVE A new technique for analyzing the morphology of the corpus callosum is presented, and it is applied to a group of elderly subjects. MATERIALS AND METHODS The proposed approach normalizes subject data into the Talairach space using an elastic deformation transformation. The properties of this transformation are used as a quantitative description… (More)
MOTIVATION The development of experimental methods for genome scale analysis of molecular interaction networks has made possible new approaches to inferring protein function. This paper describes a method of assigning functions based on a probabilistic analysis of graph neighborhoods in a protein-protein interaction network. The method exploits the fact… (More)
Conceptual representation methods play a significant role in facilitating the software process. Recent studies explore and clarify the use of these representations and their impact on progress.
Version 6.0 of the Human Genome Data Base introduces a number of significant improvements over previous releases of GDB. The most important of these are revised data representations for genes and genomic maps and a new curatorial model for the database. GDB 6.0 is the first major genomic database to provide read/write access directly to the scientific… (More)
A maintainer's understanding can go awry when it is based on purely local clues. How can we spell out the intentions behind a piece of code? A maintainer must develop an understanding of a pro-ways people talk about programs. Rich4 has developed a formal-gram if he is to carry out maintenance on it; the more ism for notating plans suitable for synthesis and… (More)
The Genome Database (GDB, http://www.gdb.org ) is a public repository of data on human genes, clones, STSs, polymorphisms and maps. GDB entries are highly cross-linked to each other, to literature citations and to entries in other databases, including the sequence databases, OMIM, and the Mouse Genome Database. Mapping data from large genome centers and… (More)
BACKGROUND AND PURPOSE Lesion-deficit-based structure-function analysis has traditionally been empirical and nonquantitative. Our purpose was to establish a new brain image database (BRAID) that allows the statistical correlation of brain functional measures with anatomic lesions revealed by clinical brain images. METHODS Data on 303 participants in the… (More)