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OBJECTIVE To develop and validate a new Simplified Acute Physiology Score, the SAPS II, from a large sample of surgical and medical patients, and to provide a method to convert the score to a probability of hospital mortality. DESIGN AND SETTING The SAPS II and the probability of hospital mortality were developed and validated using data from consecutive(More)
The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities. or concerning the delimitation of its frontiers or boundaries. The(More)
Several statistics have recently been proposed for the purpose of assessing the goodness of fit of an estimated logistic regression model. These statistics are reviewed and compared to other, less formal, procedures in the context of applications in epidemiologic research. One statistic is recommended for use and its computation is illustrated using data(More)
RATIONALE ICU-acquired paresis (ICUAP) is common in survivors of critical illness. There is significant associated morbidity, including prolonged time on the ventilator and longer hospital stay. However, it is unclear whether ICUAP is independently associated with mortality, as sicker patients are more prone and existing studies have not adjusted for this.(More)
OBJECTIVE To revise and update models in the Mortality Probability Model (MPM II) system to estimate the probability of hospital mortality among 19,124 intensive care unit (ICU) patients that can be used for quality assessment within and among ICUs. DESIGN AND SETTING Models developed and validated on consecutive admissions to adult medical and surgical(More)
Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF). The purpose of this study is to determine if the stress hormone norepi can influence(More)
Logistic regression models are frequently used in epidemiological studies for estimating associations that demographic, behavioral, and risk factor variables have on a dichotomous outcome, such as disease being present versus absent. After the coefficients in a logistic regression model have been estimated, goodness-of-fit of the resulting model should be(More)
OBJECTIVE To develop an objective method for assessing organ dysfunction among intensive care unit (ICU) patients on the first day of the ICU stay. DESIGN AND SETTING Physiological variables defined dysfunction in 6 organ systems. Logistic regression techniques were used to determine severity levels and relative weights for the Logistic Organ Dysfunction(More)
BACKGROUND The logistic regression model is being used with increasing frequency in all areas of public health research. In the calendar year 1989, over 30% of the articles published in the American Journal of Public Health employed some form of logistic regression modeling. In spite of this increase, there has been no commensurate increase in the use of(More)