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  • Stanley B Prusiner
  • Medicine, Biology
  • Science
  • 1991 (First Publication: 14 June 1991)
  • Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann-Straussler-Scheinker diseasesContinue Reading
  • R. Channing Moore, Inyoul Y. Lee, +18 authors David Westaway
  • Biology, Medicine
  • Journal of molecular biology
  • 1999 (First Publication: 1 October 1999)
  • The novel locus Prnd is 16 kb downstream of the mouse prion protein (PrP) gene Prnp and encodes a 179 residue PrP-like protein designated doppel (Dpl). Prnd generates major transcripts of 1.7 and 2.7Continue Reading
  • C Korth, Barnaby C. H. May, Fred E. Cohen, Stanley B Prusiner
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 14 August 2001)
  • Prion diseases in humans and animals are invariably fatal. Prions are composed of a disease-causing isoform (PrPSc) of the normal host prion protein (PrPC) and replicate by stimulating the conversionContinue Reading
  • Albert Taraboulos, Michael K. Scott, Arthur Semenov, Dana Avrahami, Levai Laszlo, Stanley B Prusiner
  • Biology, Medicine
  • The Journal of cell biology
  • 1995 (First Publication: 1 April 1995)
  • After the cellular prion protein (PrPC) transits to the cell surface where it is bound by a glycophosphatidyl inositol (GPI) anchor, PrPC is either metabolized or converted into the scrapie isoformContinue Reading