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BACKGROUND Canine (MDCK) cells and chicken eggs are usually used for isolation of human influenza viruses. Viruses isolated by these procedures often differ from those present in the clinical specimens, since adaptive changes occur during virus transmission from the human host to cells of heterologous origin. OBJECTIVES To minimize these species-dependent(More)
127 Influenza A virus genome consists of eight segments of RNA with negative-sense polarity (negative-strand RNA virus). Positive-sense mRNAs, from which 11 viral polypeptides are translated, are synthesized on the basis of these genomic RNAs in infected cells. In this study, we analyzed the primary structure of the genome of modern influenza A viruses(More)
PURPOSE Most colon cancers show low sensitivity to treatment with oxaliplatin and a specific strategy is needed to overcome this problem. Our approach uses RNA interference to silence the expression of target genes responsible for the development of oxaliplatin resistance. Profile analysis of genes related to the regulation of apoptosis allowed(More)
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