Stanislav I. Alekseev

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The effect of sulfhydryl reagents on macroscopic inactivation of A-current in internally perfused Lymnaea neurons under voltage-clamp conditions was investigated. It was found that the binding of Hg2+ rather than PHMB with channel proteins resulted in a strong decrease of the peak current and the inactivation rate. Hg2+ markedly influenced the steady-state(More)
Microelectrode and voltage-clamp techniques were modified to record spontaneous electrical activity and ionic currents of Lymnea stagnalis neurons during exposure to a 900-MHz field in a waveguide-based apparatus. The field was pulse-modulated at repetition rates ranging from 0.5 to 110 pps, or it was applied as a continuous wave (CW). When subjected to(More)
Millimeter wave (MMW, 42.25 GHz)-induced changes in electrical activity of the murine sural nerve were studied in vivo using external electrode recordings. MMW were applied to the receptive field of the sural nerve in the hind paw. We found two types of responses of the sural nerve to MMW exposure. First, MMW exposure at the incident power density >/=45(More)
The effects of millimeter waves (mm-waves, 75 GHz) and temperature elevation on the firing rate of the BP-4 pacemaker neuron of the pond snail Lymnaea stagnalis were studied by using microelectrode techniques. The open end to a rectangular waveguide covered with a thin Teflon film served as a radiator. Specific absorption rates (SARs), measured in(More)
The aims of the present study were to calculate the specific absorption rate (SAR) and E-field distributions inside cutaneous blood vessels and in surrounding tissues (dermis and fat) depending on the frequency of millimeter wave exposure. Most calculations were performed using the finite-difference time-domain (FDTD) technique. A rectangular block of(More)
The gating mechanism of A-channels of Lymnaea neurons and the effect of tetraethylammonium (TEA) on these channels were studied using macroscopic recording techniques. Along with the fast-inactivating A-current (Iaf) described earlier we found a slow-inactivating A-current (Ias) in some neurons of the visceral ganglion. Both currents have revealed similar(More)
Macroscopic inactivation of A-current was studied in internally perfused Lymnaea neurons under voltage clamp conditions. Inactivation kinetics were satisfactorily described by the sum of two exponentials, suggesting the presence of two type inactivation. The kinetics of recovery from inactivation were exponential. The rate constants of the fast phase of(More)
Specific absorption rate (SAR) distributions in the vicinity of a thermocouple or air bubble in water and in the presence of hair or sweat duct in skin were calculated using analytical and two-dimensional impedance methods. The objects were exposed to uniform 42.25 GHz plane electromagnetic fields. Insertion of a 0.1-mm thermocouple or similarly sized air(More)
Earlier publications demonstrated that 0.9 GHz microwave exposure induced notable changes of the conductivity of modified bilayer lipid membranes (BLM) formed in holes in thin Teflon film (TF). The aims of this study were: 1) to perform detailed calculations of the microwave field distributions in holes formed in TF, using the finite-difference time-domain(More)
The effects of short-chain alcohols (methanol, ethanol and n-propanol) on the fast-inactivating, A-type, potassium current of Lymnaea neurons were examined using macroscopic recording techniques. Alcohols produced a blockade of the current and modified its inactivation mechanism. The extracellular concentrations of methanol, ethanol and n-propanol causing(More)