Stanisław Jankowski

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Ten E. coli K1 strains isolated from the urine of children with urinary tract infections were sensitive to the bactericidal action of normal human serum (NHS). The role of the particular mechanisms of complement activation was determined in the process of killing these strains, showing variable sensitivity to the bactericidal action of NHS; three mechanisms(More)
Utilization of the complement system offers potential for the elimination of tumor cells by monoclonal antibodies (mAb) immunotherapy. Activation of the complement system causes tumor cell destruction by inducing complement lysis and promoting cell-mediated killing. In addition, complement can induce a strong inflammatory response, which might enhance other(More)
BACKGROUND The susceptibility of bacteria to the bactericidal activity of serum depends on the structure and organization of the bacterial outer membrane. It is known that the structure of the O-specific polysaccharide chain of lipopolysaccharide (LPS) plays an important role in the resistance of bacteria to host immune defenses. OBJECTIVES The(More)
The bactericidal activity of normal human serum against the Gram-negative coccobacilli Acinetobacter anitratus and Acinetobacter lwoffii was studied; 12% and 84%, respectively, of the tested strains appeared to be sensitive. Thus, serum resistance may be an important factor contributing to the pathogenic potential of A. anitratus strains. Three types of(More)
The bactericidal action of serum is one of the mechanisms protecting higher organisms from infection by gram-negative bacteria. Complement (C) activation by the classical or alternative pathways plays a main role in this protective action. The bactericidal activity of normal newborn sera against some gram-negative bacteria is less efficient than that of(More)
About 11% of Escherichia coli strains isolated from patients with urinary tract infections produced capsular antigen K1. In a group of strains resistant to normal human serum the percentage of strains with K1 antigen was higher than that without this antigen. Cefotaxime and serum showed synergistic action in the bactericidal reaction against E. coli strains(More)
Normal human serum is bactericidal for all studied Shigella flexneri strains (38) belonging to nine serotypes. Six variants of bactericidal activity of serum factors for these bacteria were determined.
The susceptibility of Escherichia coli strains with K1 surface antigen (K1+) and rods without this antigen (K1-) to the bactericidal action of normal bovine serum and human normal cord serum was determined. Seventy E. coli strains (35 K1+ and 35 K1-) were isolated from urine obtained from children with urinary tract infections. The strains investigated(More)