Stan Chandler

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Infra-red thermography was used to assess bone marrow vascularity in six patients with myelofibrosis secondary to myeloproliferative disorders (four primary myelofibrosis and two primary proliferative polycythaemia). The technique was evaluated with conventional static and dynamic radio-isotopic imaging and with immunohistochemical staining of bone marrow(More)
OBJECTIVE To evaluate the patterns of silver release from selected sustained silver-release dressings and the protective role of proteins in wound exudate and wound scale. The bactericidal action of silver in chronic wound therapy is also examined. METHOD Sequential microbiological examination of wound swabs from seven patients with chronic wounds and(More)
OBJECTIVE To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). METHODS All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by(More)
Immunoglobulin G (IgG) antibodies to carcinoembryonic antigen (CEA) were labelled with radioactive indium (111In) or iodine (131I) and a comparison made of their value in locating CEA producing tumours. Eleven patients given 111In-anti-CEA had 31 tumours as judged by a combination of all techniques. Of these, 28 were detected by 111In-anti-CEA and 26 by(More)
Two quantitative techniques have been evaluated to examine whether respiratory sinus arrhythmia can be detected in atrial fibrillation. Cyclical changes in heart rate during deep breathing indicating respiratory sinus arrhythmia were seen in 11/15 control patients, but only 1/44 patients with atrial fibrillation. Power spectrum analysis suggested that more(More)
The mean fall in the platelet count following 23 routine transfusions of 3-5 units packed cells for anaemia was 32.5%. This was significantly reduced to 12.5% in 15 similar transfusions through a 40 microns microaggregate filter (P less than 0.01) and to 4.6% following five transfusions through a polyester fibre filter (P less than 0.005). In 10(More)
First-pass studies of renal blood flow using 99Tcm-DTPA have been analysed in normotensive patients and those with renal artery stenosis. One and two component models of renal blood flow were examined for their ability to discriminate between these two groups. Using a two component model, 5/7 kidneys with proven renal artery stenosis were identified, with(More)
Anti-alpha-fetoprotein (AFP) radioimmunodetection was performed in response to clinical requests in 16 patients. In two patients, assessment of a known tumour was required; the anti-AFP scans were accurate and provided useful clinical information in both cases. In the remaining 14 patients the request was for localisation of suspected recurrent tumour.(More)