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2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation*
Background: The enzyme myeloperoxidase produces chlorine bleach at sites of inflammation. Results: 2-Thioxanthines are potent mechanism-based inactivators of myeloperoxidase. Conclusion:Expand
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Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions*
Background: The 42 amino acid long amyloid beta peptide (Aβ42) plays a pivotal role in Alzheimer disease. Results: A novel assay was developed and enabled us to describe the process of Αβ42Expand
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Determination of isoprostanes in urine samples from Alzheimer patients using porous graphitic carbon liquid chromatography-tandem mass spectrometry.
F2-isoprostanes (F2-iPs) comprise four classes of isomers produced non-enzymatically by free radical attack on arachidonic acid, a component of the cell membrane. This paper describes a new methodExpand
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Porous graphitic carbon chromatography-tandem mass spectrometry for the study of isoprostanes in human cerebrospinal fluid.
F2-isoprostanes are produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. This paper describes a new method for the determination of all four classes ofExpand
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Simultaneous determination of total and free drug plasma concentrations combined with batch-wise pH-adjustment for the free concentration determinations.
  • L. Nilsson, S. Schmidt
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 1 March 2001
Batch-wise pH-adjustment of plasma samples for free concentration determinations can be performed directly in the ultrafiltration devices using a CO(2) incubator. The pH of the samples could beExpand
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Enabling urban commons
Abstract An increasing interest in commons has generated a rich literature related to co- and participatory design (PD). Besides providing examples, cases and methods, this literature often displaysExpand
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Commons-based governance in public space : user participation and inclusion
Participatory forms of park governance have been seen as means of empowering users, improving adaptation to local needs and harnessing local resources. Participatory governance has however also beenExpand
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Some factors affecting enantiomeric trace impurity determination by capillary electrophoresis using UV and laser induced fluorescence (LIF) detection
Some factors affecting enantiomeric trace impurity determination by capillary electrophoresis using UV and laser induced fluorescence (LIF) detection,
Characterization of 4L/PS-NA mice for enzyme activity, substrate concentrations as well as inflammation to model Gaucher disease
Gaucher disease is the most common lysosomal storage disease. The neuronal disease variant is characterized by aggregated protein accumulations in the brain and associated neurologicalExpand