Staffan Hildebrand

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Renal excretion of fluid and electrolytes, total kidney GFR and superficial nephron GFR were determined in 42 Sprague Dawley rats after beta-adrenergic stimulation with isoprenaline and beta-adrenergic blockade with propranolol. Isoprenaline (0.3 μg/kg · min i. v.) decreased urine volume, sodium and potassium excretion and increased urinary sodium and(More)
In the field of vascular gene therapy, targeting systems are promising advancements to improve site-specificity of gene delivery. Here, we studied whether incorporation of magnetic nanoparticles (MNP) with different magnetic properties into ultrasound sensitive microbubbles may represent an efficient way to enable gene targeting in the vascular system after(More)
The studty compares the effects of the three main types of the naturally occurring prostaglandins on renal blood flow, glomerular filtration rate, urine output, excretion of sodium, potassium, calcium and chloride, and on osmolar and free water clearance in dogs. The prostaglandins were infused into the renal artery in maximally effective doses. None of(More)
Background Cyclic GMP (cGMP) is a major mediator of relaxation in the vascular system. cGMP is produced by the enzyme soluble Guanylyl Cyclase (sGC) in response to nitric oxide (NO) released from neighbouring endothelial cells. cGMP activates Protein Kinase G (PKG), which in turn mediates vascular relaxation through phosophorylation of various targets. One(More)
A chronic graft-versus-host reaction (GVHR) was induced in adult nonirradiated (B10 x DBA/2)F 1 mice by I.V. injection of live DBA/2 (H-2 d/d) lymphocytes. Although both a class I (K/D) and a class II (I-A/I-E) incompatibility existed in the F l recipients, DBA/2 donor cells were unable to induce the severe lympho-hemopoietic depletion characteristic of(More)
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