Stacy Weinstein

Learn More
The amyloidogenic peptide beta-amyloid has previously been shown to bind to neurons in the form of fibrillar clusters on the cell surface, which induces neurodegeneration and activates a program of cell death characteristic of apoptosis. To further investigate the mechanism of Abeta neurotoxicity, we synthesized the all-D- and all-L-stereoisomers of the(More)
Crystals, diffracting best to around 3 A, have been grown from intact large and small ribosomal subunits. The bright synchrotron radiation necessary for the collection of the higher-resolution X-ray diffraction data introduces significant decay even at cryo temperatures. Nevertheless, owing to the reasonable isomorphism of the recently improved crystals of(More)
Bacterial lipopolysaccharide (LPS) elicits responses by macrophages that help the body repel infections. Recent evidence indicates that phosphatidylinositol 3-kinase (PI 3-kinase) may mediate some of these responses. Here, we show that exposing macrophages to LPS rapidly increased membrane-associated PI 3-kinase activity and also elevated p70 S6 kinase(More)
[1] The Atacama Desert, one of the most arid landscapes on Earth, serves as an analog for the dry conditions on Mars and as a test bed in the search for life on other planets. During the Life in the Atacama (LITA) 2004 field experiment, satellite imagery and ground-based rover data were used in concert with a 'follow-the-water' exploration strategy to(More)
[1] As part of the three-year 'Life in the Atacama' (LITA) project, plant and microbial abundance were mapped within three sites in the Atacama Desert, Chile, using an automated robotic rover. On-board fluorescence imaging of six biological signatures (e.g., chlorophyll, DNA, proteins) was used to assess abundance, based on a percent positive sample rating(More)
The lip stiffness characteristics in the vertical plane of a white population sample, aged 18-26, were studied. The physical properties of the lip system were analyzed and a mathematical model was derived to approximate this system. The instrumentation consisted of a force-transducer bar, a head holder and a three-directional micrometer adjustment. Four(More)
The icy moon of Europa is a hot topic in planetary exploration. This paper discusses the trajectory design of a Europa orbiter mission intended to find out if Europa is a possible habitat for extraterrestrial life. Getting into orbit at Europa is difficult; the simplest trajectory design (a direct Hohmann-type transfer to Jupiter followed by an immediate(More)
Introduction: The " Life in the Atacama " (LITA) project included two field trials during the 2004 field season, each of which lasted about a week. The remote science team had no prior knowledge of the local geology, and relied entirely on orbital images and rover-acquired data to make interpretations. The sites for these trials were in different locations,(More)
Introduction: The Life in the Atacama (LITA) project includes rover field tests designed to look for life in the arid environment of the Atacama Desert (Chile). Field instruments were chosen to help remote observers identify potential habitats and the presence of life in these habitats, and included two spectrometers for help in identifying the mineralogy(More)
[1] The scientific success of a remote exploration rover mission depends on the right combination of technology, teamwork and scientific insight. In order to quantitatively evaluate the success of a rover field trial, it is necessary to assess the accuracy of scientific interpretations made during the field test. This work compares three structured(More)