Stacy H Shoshan

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The MHC molecules present normal as well as disease-related and pathogen-derived peptides to T cells as a way of alerting the immune system of the health status of a cell. Proteomic technologies involving immunoaffinity purification are now extensively used to separate MHC complexes from their peptide cargo, and then the peptides are sequenced by tandem(More)
The repertoires of serum autoantibodies differ between healthy people and cancer patients. While in healthy individuals these autoantibodies are directed against a limited number of self-proteins, in cancer patients the antibody repertoires are much further expanded with a wider range of reactivities against other proteins. Although cancer patients clearly(More)
Proteomics is a new scientific field aimed at the large-scale characterization of the protein constituents of biologic systems. It facilitates comparisons between different protein preparations by searching for minute differences in their protein expression repertoires and the patterns of their post-translational modifications. These attributes make(More)
We would like to put forward the hypothesis that cancer patients may produce autoantibodies that promote uncontrolled cell growth and thereby function as oncogenes. Dying cells release proteins that stimulate the production of autoantibodies, an event also known to occur during the earliest stages of tumor growth. If some of these autoantibodies are(More)
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