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Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications.

• Douglas A. Greene, Staci Lattimer, Alexandra Sima
• The New England journal of medicine
• 1987

During the past decade, our appreciation of the original experiments with myo-inositol supplementation in diabetic rats has greatly expanded. The effects of myo-inositol on nerve conduction are now… (More)

Axo-glial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the spontaneously diabetic bio-breeding rat.

• Alexandra Sima, Staci Lattimer, Soroku Yagihashi, Douglas A. Greene
• The Journal of clinical investigation
• 1986

Biochemical abnormalities in peripheral nerve are thought to precede and condition the development of diabetic neuropathy, but metabolic intervention in chronic diabetic neuropathy produces only… (More)

Reduced motor nerve conduction velocity and Na(+)-K(+)-ATPase activity in rats maintained on L-fucose diet. Reversal by myo-inositol supplementation.

• Mark A Yorek, Tom Wiese, +7 authors Alexandra Sima
• Diabetes
• 1993

L-Fucose is a monosaccharide that occurs in low concentrations in normal serum but has been shown to be increased in diabetic individuals. In cultured mammalian cells, L-fucose is a potent… (More)

Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation.

• Douglas A. Greene, Staci Lattimer
• The Journal of clinical investigation
• 1983

Nerve conduction impairment in experimental diabetes has been empirically but not mechanistically linked to altered nerve myo-inositol metabolism. The phospholipid-dependent membrane-bound… (More)

Aldose reductase inhibitors: an approach to the treatment of diabetic nerve damage.

• Douglas A. Greene, Alexandra Sima, +6 authors Staci Lattimer
• Diabetes/metabolism reviews
• 1993

Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat

• M. J. Stevens, Staci Lattimer, Mikiko Kamijo, C. Van Huysen, A. A. F. Sima, Douglas A. Greene
• Diabetologia
• 1993

Diabetic neuropathy results from progressive nerve fibre damage with blunted nerve regeneration and repair and may be complicated by nerve hyperexcitability resulting in pain. The naturally occurring… (More)

Complications: neuropathy, pathogenetic considerations.

• Douglas A. Greene, Alexandra Sima, M. J. Stevens, E. L. Feldman, Staci Lattimer
• Diabetes care
• 1992

The most common form of neuropathy associated with diabetes mellitus is distal symmetric sensorimotor polyneuropathy, often accompanied by autonomic neuropathy. This disorder is characterized by… (More)

The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.

• M. J. Stevens, Jamie Dananberg, +6 authors Douglas A. Greene
• The Journal of clinical investigation
• 1994

Metabolic and vascular factors have been invoked in the pathogenesis of diabetic neuropathy but their interrelationships are poorly understood. Both aldose reductase inhibitors and vasodilators… (More)

Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.

• Alexandra Sima, Helen Ristic, +4 authors Douglas A. Greene
• The Journal of clinical investigation
• 1996

The abnormalities underlying diabetic neuropathy appear to be multiple and involve metabolic neuronal and vasomediated defects. The accumulation of long-chain fatty acids and impaired beta-oxidation… (More)

Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil.

• Alexandra Sima, Vera Bril, +4 authors Douglas A. Greene
• The New England journal of medicine
• 1988

There is reason to believe that diabetic neuropathy may be related to the accumulation of sorbitol in nerve tissue through an aldose reductase pathway from glucose. Short-term treatment with aldose… (More)

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