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RATIONALE Exposure to inescapable stressors increases both the rewarding properties and self-administration of cocaine through the signaling of the kappa-opioid receptor (KOR), but the effect of this signaling on other reinforcing agents remains unclear. OBJECTIVE The objective of this study is to test the hypothesis that signaling of the KOR mediates the(More)
As a major neuropathogenic factor associated with human immunodeficiency virus (HIV) infection, HIV-1 Tat protein is known to synergize with psychostimulant drugs of abuse to cause neurotoxicity and exacerbate the progression of central nervous system pathology. However, the functional consequences of the interaction between HIV-1 Tat and abused drugs on(More)
The Northeast Under/Graduate Research Organization for Neuroscience (NEURON) was established 12 years ago in order to foster the training, education, and research of both undergraduate and graduate neuroscience students. NEURON hosts two annual conferences (Boston in the fall; New York City in the spring) to promote and support neuroscience training,(More)
Maladaptive behavioral responses characteristic of post-traumatic stress disorders are notably resistant to treatment. We hypothesized that the pharmacological disruption of memories activated during reconsolidation might reverse established stress-induced increases in depression-like behaviors and cocaine reward. C57BL/6J mice were subjected to repeated(More)
High consumption of fruits and vegetables has been associated with reduced risk of debilitating diseases and improved cognition in aged populations. These beneficial effects have been attributed to the phytochemicals found in fruits and vegetables, which have previously been shown to be anti-inflammatory and modulate autophagy. Tart cherries contain a(More)
Studies using a ground-based system (NASA Space Radiation Laboratory) to examine the effects of exposure to high-energy charged particles or HZE particles on cognitive performance have interchangeably used whole-body exposures or exposures restricted to the head of the subject. For this study, we hypothesized that different types of exposure such as whole(More)
Introduction: When rats and mice are exposed to HZE particles at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory to simulate the effect of exposure to space radiation on cognitive performance, there may be differences in the amount of tissue that is irradiated: some experimenters irradiate only the head, whereas others irradiate(More)
INTRODUCTION The Northeast Under/Graduate Research Organization for Neu-roscience (NEURON; www.albany.edu/neuron/conference/ index.html) was established 12 years ago to foster the training , education, and research of both undergraduate and graduate neuroscience students. NEURON hosts two annual conferences (Boston in the fall; New York City in the spring)(More)
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