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PURPOSE The present study was conducted to determine the rate of sudden unexplained death in epilepsy (SUDEP) in a well-defined cohort of patients included in the lamotrigine (LTG) clinical development database. METHODS A panel of scientists experienced in the area of SUDEP was assembled and provided with case summaries on all deaths (n = 45) reported(More)
Over a period of 6 years, 251 infants under 6 months of age underwent repair of inguinal hernias (IH; n = 311). There were 241 males and 10 females. Incarceration occurred in 59 infants (24%), one of whom had bilateral incarceration. As a result of the authors' policy to operate on infantile IH within 7 days of diagnosis, only 6% of the incarcerations(More)
Pulmonary lobectomy in the presence of infected secretions requires isolation of the affected lung to prevent soiling of the healthy lung. In young children this is usually accomplished using a Fogarty embolectomy catheter. We report the successful combination of a Fogarty catheter, a tracheal tube and the prone position, which provided adequate ventilation(More)
The variability and relative bioavailability of methylprednisolone tablets were evaluated utilizing a double Latin square crossover design in which each of 20 subjects was given four of five treatments. Three different lots of methylprednisolone tablets exhibited virtually identical absorption, with similar ranges and coefficients of variation of some(More)
A case of traumatic chylothorax following a motor vehicle accident is presented. This is a rare injury following thoracic trauma and is associated with a high mortality and morbidity. Mechanisms of injury to the thoracic duct are described. A management strategy is suggested, which initially entails a trial of conservative therapy of adequate drainage,(More)
Unilateral cryptorchidism was induced in Wistar rat pups within 48 hours of birth. Evaluation of fertility was subsequently assessed at 50, 100, and 150 days of age by paternity and daily sperm production. The descended scrotal testis was demonstrated to have a significantly diminished rate of sperm production at 150 days. Paternity studies failed to(More)
During an 8-year period, 51 children with neurogenic bladder had endoscopic injection of Teflon (STING) for the management of 69 refluxing ureters. There were 21 boys and 30 girls (age range, 10 month to 16 years). Vesico-ureteral reflux (VUR) had been present for a mean of 4.1 years, and severity distribution was as follows: grade I, 1 ureter; grade II, 5(More)
AIM To see whether increasing use of ultrasound scans in pyloric stenosis is leading to false-positive diagnoses, and even negative laparotomies. METHODS Over a 2-year period, 76 neonates underwent laparotomy with a preoperative diagnosis of pyloric stenosis (PS). There were 57 males and 19 females, age ranged from 10 days to 7 weeks. RESULTS Six(More)
Over a 6-year period, 14 infants with a total of 16 inguinal hernias (IH) underwent transperitoneal closure of the internal ring (TPIR). This was performed through a minilaparotomy, using a purse-string suture placed around the internal ring from within. A difficult inguinal dissection of an edematous and friable spermatic cord was avoided. TPIR was(More)