Stéphanie Sirard

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BACKGROUND Oral vancomycin (125 mg qid) is recommended as treatment of severe Clostridium difficile infection (CDI). Higher doses (250 or 500 mg qid) are sometimes recommended for patients with very severe CDI, without supporting clinical evidence. We wished to determine to what extent faecal levels of vancomycin vary according to diarrhoea severity and(More)
1Department of Microbiology-Infectious Diseases, Université de Sherbrooke, Sherbrooke, Quebec; 2Department of Medicine, Royal Inland Hospital, Kamloops, British Columbia; 3Departments of Medicine, Critical Care Medicine, Pathology and Laboratory Medicine, and Community Health Sciences, University of Calgary, Calgary, Alberta The prevalence of obesity is(More)
Clostridium difficile strain NAP1/027 (North American pulsed-field gel electrophoresis [PFGE] type 1 and PCR ribotype 027 [R027]) has been associated with recent outbreaks in North America and Europe. It has been associated with more severe disease symptoms, higher mortality rates, and greater risk of relapse. This strain is thought to produce more toxins(More)
BACKGROUND Clostridium difficile infection (CDI) can lead to complications, recurrence, and death. Numerous studies have assessed risk factors for these unfavourable outcomes, but systematic reviews or meta-analyses published so far were limited in scope or in quality. METHODS A systematic review was completed according to PRISMA guidelines. An electronic(More)
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