Stéphanie Lerondel

Alain Le Pape3
Julien Sobilo2
Benjamin Brillet1
3Alain Le Pape
2Julien Sobilo
1Benjamin Brillet
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Tissue factor pathway inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin which activates matrix metalloproteinases (MMPs) involved in degradation of the extracellular matrix. Its secretion in the tumour microenvironment makes TFPI-2 a potential inhibitor of tumour invasion and metastasis. As demonstrated in aggressive cancers, TFPI-2 is frequently(More)
  • Guillaume Desoubeaux, Janice M. Reichert, Matthew Sleeman, Karen L. Reckamp, Bernhard Ryffel, Jörg P. Adamczewski +8 others
  • 2016
Monoclonal antibody (mAb) therapeutics have tremendous potential to benefit patients with lung diseases, for which there remains substantial unmet medical need. To capture the current state of mAb research and development in the area of respiratory diseases, the Research Center of Respiratory Diseases (CEPR-INSERM U1100), the Laboratory of Excellence(More)
Olfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect odorants, but also in other tissues with additional functions. Some ORs are even overexpressed in tumor cells. In this study, we identified ORs expressed in enterochromaffin tumor cells by RT-PCR, showing that single cells can co-express several ORs. Some of the receptors(More)
OBJECTIVES We have developed a relevant preclinical model associated with a specific imaging protocol dedicated to onco-pharmacology studies in mice. MATERIALS AND METHODS We optimized both the animal model and an ultrasound imaging procedure to follow up longitudinally the lung tumor growth in mice. Moreover we proposed to measure by photoacoustic(More)
BACKGROUND The assessment of anticancer agents to treat leukemia needs to have animal models closer to the human pathology such as implantation in immunodeficient mice of leukemic cells from patient samples. A sensitive and early detection of tumor cells in these orthotopic models is a prerequisite for monitoring engraftment of leukemic cells and their(More)
Bioluminescence imaging is a recent modality to visualize biological effects more especially for small animals. However the acquired images are degraded by diffusion and absorption phenomena from the tissue and by the acquisition system itself. In this paper, we use restoration methods to enhance the quality of bioluminescence images. We propose a model for(More)
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