Stéphanie Légaré

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The treatment of breast cancer has benefitted tremendously from the generation of estrogen receptor-α (ERα)-targeted therapies, but disease relapse continues to pose a challenge due to intrinsic or acquired drug resistance. In an effort to delineate potential predictive biomarkers of therapy responsiveness, multiple groups have identified several(More)
Approximately 70% of breast cancers express the estrogen receptor (ER)α and are treated with the ERα antagonist, tamoxifen. However, resistance to tamoxifen frequently develops in advanced breast cancer, in part due to a down-regulation of ERα corepressors. Nuclear receptor corepressors function by attenuating hormone responses and have been shown to(More)
development of foraging in juvenile Palila, an endangered Hawaiian honeycreeper found only on Mauna Kea on the island of Hawaii. Though incidental observations of helpers-at-the-nest have been made, intensive nest monitoring revealed that 30 to 50% of nests had one extra after-second-year male provisioning food to the nestling(s). Helping at the fledgling(More)
The primary cilium is a microtubule-based and nonmotile organelle functioning as a cellular antenna that is involved in the regulation of cell proliferation, differentiation, and migration. In breast cancer cells, the primary cilium is a structure that decreases in incidence with increasing degrees of transformation and may be biologically more important in(More)
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