Stéphanie Delga

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Iron and copper are essential trace metals, actively absorbed from the proximal gut in a regulated fashion. Depletion of either metal can lead to anemia. In the gut, copper deficiency can affect iron absorption through modulating the activity of hephaestin - a multi-copper oxidase required for optimal iron export from enterocytes. How systemic copper status(More)
Helicobacter pylori infection triggers chronic inflammation of the gastric mucosa that may progress to gastric cancer. The hypoxia-inducible factors (HIFs) are the central mediators of cellular adaptation to low oxygen levels (hypoxia), but they have emerged recently as major transcriptional regulators of immunity and inflammation. No studies have(More)
Maintenance of iron homeostasis is critical, as iron deficiency can lead to anemia while iron overload is toxic and detrimental to human health. Since humans do not possess a regulated iron excretion pathway, iron homeostasis must be tightly regulated at the level of intestinal absorption. Hypoxia Inducible Factors (HIFs), HIF-1 and HIF-2, are central(More)
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