Stéphane Mathieu

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Ectopic production of free beta human chorionic gonadotrophin (hCGbeta) by bladder carcinoma is well described and occurs in approximately 35% of cases. hCGbeta secreting tumours are more aggressive, radioresistant and have a greater propensity to metastasize. We proposed that the ectopic production of hCGbeta was contributing in an autocrine fashion to the(More)
After pulp amputation, complete pulp healing requires not only reparative dentin production but also fibroblast proliferation, nerve fiber growth, and neoangiogenesis. This study was designed to investigate the role of pulp fibroblasts in angiogenesis. Human pulp fibroblasts from third molars co-cultured with human umbilical vein endothelial cells induced(More)
AIM To investigate the expression of two endoplasmic reticulum (ER)-resident key chaperone proteins, ERdj5 and BiP, under the influence of resinous monomers and its relationship with the inhibition of mineralization caused by the monomer 2-hydroxyethyl methacrylate (HEMA). METHODOLOGY The ERdj5 and BiP expression was studied in vitro, in primary human(More)
BACKGROUND Objective control of intestinal inflammation during inflammatory bowel disease (IBD) is becoming the main driver for medical treatment. However, the monitoring tools-related burden remains poorly investigated. We aimed to evaluate their comparative acceptability and utility according to patients with IBD. METHODS After a preliminary phase, the(More)
Selectins belong to the family of adhesion molecules that recognize sugars as ligands through their Carbohydrate Recognition Domain (CRD). There are three types of selectin: the L-selectin (CD62L), which is constitutively expressed by most leukocyte populations, the P-selectin (CD62P) is found on activated platelets and endothelial cells, and the E-selectin(More)
Thyrostats have been banned for use as veterinary drugs in Europe since 1981 because of their carcinogenic and teratogenic properties. Until now, the identification of thiouracil in animal biological matrices has been interpreted as the consequence of an illegal administration. The present paper studies the influence of a cruciferous-based feed on the(More)
Platelet adhesion, the initial step of platelet activation, is mediated by the interaction of von Willebrand factor (VWF) with its platelet receptor, the GPIb-IX complex. The binding of VWF to GPIb-IX is induced either by increased shear stress or by exogenous modulators, such as botrocetin. At a molecular level, this interaction takes place between the A1(More)
Two TaC-strengthened cobalt-based alloys, with compositions Co-10Cr-0.25C-4.4Ta and Co-10Cr-0.5C-8.7Ta (wt.%) underwent Cr-deposition by pack-cementation, followed by heat-treatment to allow Cr diffusing deeper in their sub-surface. Thereafter they were tested for 50 hours at 1200°C in a thermobalance. These alloys were successfully enriched in chromium,(More)
A proposed design for Generation IV nuclear systems is a sodium-cooled fast reactor (SFR) [1]. The use of liquid sodium as a coolant requires a high-performance fuel cladding material. One candidate is vanadium alloy V4Cr4Ti [2]; however, because of vanadium’s high affinity for oxygen, an oxygen concentration as low as 1 ppm in Na [2] provokes vanadium(More)
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