Stéphane Debeugny

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BACKGROUND Environmental factors are believed to trigger the onset of Crohn's disease (CD) in genetically susceptible individuals. The aim of this study was to assess environmental and familial factors that might be etiologically related to CD. METHODS Twenty-one families with 3 or more affected first-degree relatives were studied, together with 10(More)
BACKGROUND & AIMS The rarity of inflammatory bowel disease (IBD) in both husband and wife is often given as an argument against an infectious origin. We registered conjugal instances of IBD in Northern France and in Belgium between 1989 and 2000. METHODS Couples were assigned to group A if both partners had symptoms of IBD before cohabitation, to group B(More)
BACKGROUND AND AIMS Stress is often perceived by patients with inflammatory bowel disease (IBD) as the leading cause of their disease. The aim of this study was to assess whether stress, evaluated through life event (LE) occurrence, is associated with IBD onset. METHODS Incident cases of IBD, including 167 patients with Crohn's disease (CD) and 74 with(More)
BACKGROUND Environmental exposures in early life have been implicated in the aetiology of inflammatory bowel disease. OBJECTIVE To examine environmental risk factors prior to the development of inflammatory bowel disease in a paediatric population based case control study. METHODS A total of 222 incident cases of Crohn's disease and 60 incident cases of(More)
BACKGROUND Recently we published an analysis of environmental factors in familial Crohn's disease (CD) in Belgium. The aim of the current study was to assess pedigrees and sibships, temporal relationships among cases, and family circumstances relevant to the frequency or onset of CD. STUDY Twenty-one families with 3 or more affected first-degree relatives(More)
There are no international guidelines for an appropriate and cost-effective follow-up for resected nonsmall cell lung cancer (NSCLC). We retrospectively reviewed the outcome of NSCLC patients after curative surgery. Follow-up included physical examination and chest radiography every 3 months, and chest computed tomography (CT) scan, bronchoscopy, abdominal(More)
INTRODUCTION Severe attacks of neuromyelitis optica spectrum disorder (NMO-SD) are improved by plasma exchange (PLEX) given as an adjunctive therapy. Initial studies failed to demonstrate a delay of PLEX treatment influenced clinical outcome; however PLEX was always used late. We examine the clinical consequences of delay in PLEX initiation on severe optic(More)
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