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OBJECTIVES This study evaluates the clinical impact of adjusting the loading dose of clopidogrel according to vasodilator-stimulated phosphoprotein (VASP) index in patients with clopidogrel resistance undergoing percutaneous coronary intervention (PCI). BACKGROUND Clopidogrel resistance plays a key role in ischemic recurrence after PCI. In vitro tests of(More)
BACKGROUND Periodontal disease (PD) has been recognized as a risk factor for systemic diseases, but its involvement in the pathogenesis of coronary artery disease (CAD) remains debated. OBJECTIVES We sought to evaluate the potential relations between severity of the PD, inflammatory response and angiographic lesions extent in patients with stable CAD. (More)
BACKGROUND Based on the hypothesis that it reflects left ventricular (LV) diastolic pressures, B-type natriuretic peptide (BNP) is largely utilized as first-line diagnostic complement in the emergency diagnosis of congestive heart failure (HF). The incremental diagnostic value of tissue Doppler echocardiography, a reliable noninvasive estimate of LV filling(More)
The imbalance of Starling's forces was investigated in 25 elderly patients hospitalized for acute diastolic heart failure. Tissue Doppler evidence of elevated left ventricular filling pressures was present on admission in 17 patients with high B-type natriuretic peptide (BNP) levels. Serum proteins concentrations and colloid osmotic pressure, related to(More)
Stent thrombosis remains a significant pitfall of percutaneous coronary intervention (PCI). A recent trial observed that an adjusted loading dose (LD) of clopidogrel according to platelet monitoring decreases the rate of major adverse cardiovascular events after PCI. We investigated if such a strategy of a tailored clopidogrel LD according to platelet(More)
OBJECTIVES We aimed to investigate the biological impact of a tailored clopidogrel loading dose (LD) according to platelet reactivity monitoring in carriers of the cytochrome (CYP) 2C19*2 loss-of-function polymorphism undergoing percutaneous coronary intervention for an acute coronary syndromes. BACKGROUND CYP2C19*2 polymorphism is associated with reduced(More)
The aim of this study was to assess the accuracy of flow propagation velocity by color M-mode (Vp) and peak early diastolic mitral annulus velocity by tissue Doppler (Ea) in identifying pseudonormal mitral filling in 25 patients with acute symptoms of heart failure and preserved left ventricular systolic function compared with 25 gender- and age-matched(More)
We evaluated the prognostic value of plasma N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) in 71 transplanted heart recipients during a 38 +/- 2 month follow-up. The negative predictive value of NT-pro-BNP levels </=800 pg/ml to predict death was 97% (95% confidence interval 92 to 100). Thus, NT-pro-BNP levels </=800 pg/ml predict a middle-term good(More)
Congestive heart failure with preserved left ventricular systolic function has emerged as a growing epidemic medical syndrome in developed countries, which is characterized by high morbidity and mortality rates. Rapid and accurate diagnosis of this condition is essential for optimizing the therapeutic management. The diagnosis of congestive heart failure is(More)
INTRODUCTION High on-treatment platelet reactivity (HTPR) after clopidogrel loading dose (LD) is associated with a high risk of thrombotic events after percutaneous coronary intervention(PCI). We have demonstrated that HTPR could be overcome in the majority of cases using LD adjustment resulting in an improved clinical outcome. However this strategy failed(More)