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  • Mai Quỳnh Nguyễn, Richard C. Marcellus, +14 authors Gordon C. Shore
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 4 December 2007)
  • Elevated expression of members of the BCL-2 pro-survival family of proteins can confer resistance to apoptosis in cancer cells. Small molecule obatoclax (GX15-070), which is predicted to occupy aContinue Reading
  • Houtan Moshiri, Stéphane Acoca, +4 authors Reza Salavati
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2011 (First Publication: 4 March 2011)
  • RNA editing, catalyzed by the multiprotein editosome complex, is an essential step for the expression of most mitochondrial genes in trypanosomatid pathogens. It has been shown previously thatContinue Reading
  • Gordon C. Shore, Mark A. Watson, +12 authors Dolors Colomer
  • Biology
  • 2006 (First Publication: 16 November 2006)
  • Obatoclax (GX15-070), a synthetic small molecule pan-Bcl-2 family inhibitor, is currently under investigation in multiple Phase II trials directed at hematologic and solid tumor malignancies.Continue Reading