Srinivas V. Goverdhan

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Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and(More)
PURPOSE To evaluate whether Chlamydia (C.) infections are associated with age-related macular degeneration (AMD) and to assess if this association is influenced by the complement factor H (CFH) Y402H or the high temperature requirement A serine peptidase 1 (HTRA1) rs11200638 risk genotypes. METHODS One hundred ninety-nine AMD patients with early and late(More)
A 54-year-old gentleman presented to our Eye Unit following an optician referral with a 4-month history of gradual visual deterioration. Other significant symptoms included problems with his mobility and balance consistent with an ataxic sensory neuropathy for which he had not sought medical advice. History revealed a significant amount of cigarette smoking(More)
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