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A novel blue fluorescent chlorophyll catabolite accumulates in senescent leaves of the peace lily and indicates a split path of chlorophyll breakdown
The findings on ‘hypermodified’ FCCs call for attention as to possible physiological roles of Chl‐catabolites in plants, and stabilize FCCs against their typical and rapid isomerization to NCCs. Expand
Hypermodified fluorescent chlorophyll catabolites: source of blue luminescence in senescent leaves.
Chlorophyll breakdown was suggested to follow a common path in senescence and fruit ripening, and to yield NCCs as its “final” product. Expand
Thioamides in Nature: In Search of Secondary Metabolites in Anaerobic Microorganisms
Thioamides are formed by replacing the carbonyl oxygen in an amide bond with sulfur (HN C=S), and have been considered as an isosteric replacement in Biophysicists and medicinal chemists employ thioamide substitutions in the backbone of peptides and other amide-containing compounds to improve stability in proteolytic degradation and improve the ADME properties of amides. Expand
Chlorophyll Breakdown in Senescent Banana Leaves: Catabolism Reprogrammed for Biosynthesis of Persistent Blue Fluorescent Tetrapyrroles
The massive accumulation of the hmFCCs in banana leaves, and their functional group characteristics, indicate a chlorophyll breakdown path, the downstream transformations of which are entirely reprogrammed towards the generation of persistent and blue fluorescent FCCs. Expand
"Blackening" porphyrins by conjugation with quinones.
Making use of the dienophilic and oxidative properties of quinones, this work has achieved an effectively irreversible attachment of up to four electronically conjugated benzoquinone units, giving porphyrins with systematically extended p systems. Expand
Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers.
It is shown that strong tumor accumulation does not automatically mean high cellular uptake and that the nanocarriers' size plays a critical role in cell- and compartment-specific drug targeting, implying that drug carriers with sizes in the range of therapeutic antibodies show balanced properties with respect to passive accumulation, tissue penetration, and active targeting. Expand
Total synthesis of the ribosomally synthesized linear azole-containing peptide plantazolicin A from Bacillus amyloliquefaciens.
Total Synthesis of the Ribosomally Synthesized Linear Azole-Containing Peptide Plantazolicin A from Bacillus amyloliquefaciens A cyclodehydration reaction has been used to synthesize the linearExpand
Photochemical studies of a fluorescent chlorophyll catabolite--source of bright blue fluorescence in plant tissue and efficient sensitizer of singlet oxygen.
The efficient generation of singlet oxygen makes fluorescent chlorophyll catabolites phototoxic, but might also be useful as a (stress) signal and for defense of the plant tissue against infection by pathogens. Expand
Porphyrin-LEGO®: synthesis of a hexafullereno-diporphyrin using porphyrins programmed for [4+2]-cycloaddition.
A hexafullereno-diporphyrinoid was obtained in a sequence of cycloaddition steps using porphyrins programmed for [4+2]-cycloaddition reactions and C(60)-fullerene.
Arg-Thz is a minimal substrate for the N(α),N(α)-arginyl methyltransferase involved in the biosynthesis of plantazolicin.
It is shown that PznL processes truncated desmethyl-plantazolicin analogues, but only those with an N-terminal guanidine side chain derived from arginine, and specificity depends on the side chain of the N- terminal amino acid linked to an azole. Expand