Sridharakumar Narasimhan

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The study of gene regulatory networks is a significant problem in systems biology. Of particular interest is the problem of determining the unknown or hidden higher level regulatory signals by using gene expression data from DNA microarray experiments. Several studies in this area have demonstrated the critical aspect of the network structure in tackling(More)
In our previous work on " self-optimizing control " we look for simple control policies to implement optimal operation. In particular, we have looked at " what should we control " (choice of controlled variables (CV 's)). For quadratic problems with linear constraints, optimal linear variable combinations c = Hy may be obtained. In this work, we apply these(More)
— System Identification is the process of constructing an accurate and reliable dynamic mathematical model of the system from observed data and available knowledge. The choice of inputs used for perturbing the system is critical in the identification and model building exercise. One of the major objectives of system identification is accurate estimation of(More)
A statistical p r o c e d u r e for determining whether p r o c e s s variables h a v e undergone a c h a n g e of s t e a d y s t a t e s is d e v e l o p e d by using a com-p o s i t e statistical t e s t. F a c t o r s influencing t h e p o w e r of t h e t e s t a n d t h e probability of T y p e I errors were studied through theoretical analysis,(More)
Model predictive control (MPC) is a favored method for handling constrained linear control problems. Normally, the MPC optimization problem is solved on-line, but in ‘explicit MPC’ an explicit precomputed feedback law is used for each region of active constraints (Bemporad et al., 2002). In this paper we make a link between this and the ‘self-optimizing(More)
The title compound, C(26)H(24)O(5), was isolated from calophyllum inophyllum seeds. In the mol-ecule, the phenyl and 2-methyl-but-2-enoyl groups are almost orthogonal to the chromene fragment [C-C-C-C torsion angles = 81.4 (3) and -90.1 (2)°, respectively]. In the crystal packing, centrosymmetrically related mol-ecules are linked by C-H⋯O contacts into(More)