Srdana Grgurevic

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Approximately 1,000 microRNAs (miRs) are present in the human genome; however, little is known about the regulation of miR transcription. Because miR levels are deregulated in chronic lymphocytic leukemia (CLL) and signal transducer and activator of transcription (STAT)-3 is constitutively activated in CLL, we sought to determine whether STAT3 affects the(More)
MicroRNA (miR) abnormalities play a key role in the pathogenesis of chronic lymphocytic leukemia (CLL). High levels of miR-155 have been detected in human neoplasms, and overexpression of miR-155 has been found to induce lymphoma in mice. High levels of miR-155 were detected in CLL cells and STAT3, which is known to induce miR-21 and miR-181b-1 expression,(More)
DNA transactions, including replication, repair of damaged DNA and recombination (the so-called '3Rs') are crucial processes required for preserving genome integrity and limiting cancer risk. 1 Our previous large-scale studies performed in solid cancers displaying major genetic instabilities, demonstrated that specific misexpression of DNA replication genes(More)
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