Spyros Tsikrikas

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Catheter ablation of atrial fibrillation (AF) has been widely accepted as an important therapeutic modality for the treatment of patients with symptomatic, drug-refractory AF. Ablation strategies which target the pulmonary veins (PVs) and/or the PV antrum (segmental or large circumferential lesions) are the cornerstone of AF ablation procedures,(More)
Drug-induced proarrhythmia represents a great challenge for those involved in the development of novel pharmaceuticals and in the regulatory bodies for drug approval as well as for the prescribing clinicians. Our understanding of the mechanisms that underlie drug-induced proarrhythmia has grown dramatically over the last two decades. A growing number of(More)
Amiodarone is a widely used antiarrhythmic drug whose use is significantly limited by numerous undesirable effects following long-term administration. In the literature so far, it has been reported that the most common acute adverse effect of the intravenous administration of amiodarone requiring intervention is hypotension. We present the case of a female(More)
BACKGROUND Risk stratification of asymptomatic individuals with type 1 electrocardiogram (ECG) phenotype of Brugada syndrome (BS) still remains controversial. This study investigated the long-term prognosis of asymptomatic subjects with spontaneous or drug-induced type 1 ECG pattern of BS. METHODS AND RESULTS Data from 33 apparently healthy individuals(More)
Atrial fibrillation (AF) is associated with an increased risk of cardiac and overall mortality. Restoration and maintenance of sinus rhythm is of paramount importance if it can be accomplished without the use of antiarrhythmic drugs. Catheter ablation has evolved into a well-established treatment option for patients with symptomatic, drug-refractory AF.(More)
Idiopathic, focal ventricular tachycardia that originates from the right ventricular apex is presented. Arrhythmogenic ventricular dysplasia needs to be ruling out prior to making this diagnosis. This is a rare entity that can be cured with an ablation and therefore it needs to be considered in the differential diagnosis of idiopathic VTs before implanting(More)
AIM The presence of early repolarization (ER) in inferior or inferolateral leads has been associated with malignant arrhythmias and increased mortality. Transmural dispersion of repolarization (TDR) has been proposed to underlie arrhythmogenesis in J-wave syndromes. The present study investigated specific electrocardiographic (ECG) markers including(More)
BACKGROUND Accumulating data have shown that the autonomic nervous system is strongly implicated in the genesis of atrial fibrillation (AF). The aim of this study was to assess the efficacy of a single ablation procedure in patients with vagotonic, adrenergic and random type of paroxysmal AF. METHODS AND RESULTS The clinical records of consecutive(More)