Spyros Papapetropoulos

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OBJECTIVE The focus of this review is to review potential diagnostic and therapeutic biomarkers associated with migraine. BACKGROUND Migraine headache is a common disease that affects millions of individuals worldwide. Although well-accepted diagnostic criteria exist for migraine, it is still a complex disorder that remains both underdiagnosed and(More)
PARKINSON’S DISEASE IS A COMMON HEALTH CARE PROBLEM WITH SIGNIFICANT SOCIAL AND ECONOMIC IMPLICATIONS More than one million people in the US (five million people worldwide) are believed to have Parkinson’s disease, and its prevalence is expected to double by 2030 (1). The national annual economic burden for Parkinson’s disease in 2010 was estimated at more(More)
The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible(More)
Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential of laquinimod (1 and 10 mg/kg), a novel immunomodulatory agent shown to be protective in a number of neuroinflammatory conditions, in the YAC128 mouse model of HD. Treatment with(More)
PURPOSE Options for leveraging available telemedicine technologies, ranging from simple webcams and telephones to smartphone apps and medical-grade wearable sensors, are evolving faster than the culture of clinical research. Until recently, most clinical trials relied on paper-based processes and technology. This cost- and labor-intensive system, while(More)
OBJECTIVES To assess the feasibility, predictive value, and user satisfaction of objectively quantifying motor function in Parkinson's disease (PD) through a tablet-based application (iMotor) using self-administered tests. METHODS PD and healthy controls (HCs) performed finger tapping, hand pronation-supination and reaction time tasks using the iMotor(More)
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