Spyros Kollias

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PURPOSE Rechallenge with temozolomide (TMZ) at first progression of glioblastoma after temozolomide chemoradiotherapy (TMZ/RT→TMZ) has been studied in retrospective and single-arm prospective studies, applying temozolomide continuously or using 7/14 or 21/28 days schedules. The DIRECTOR trial sought to show superiority of the 7/14 regimen. EXPERIMENTAL(More)
A haptic interface compatible with the Magnetic Resonance (MR) imaging technique allows tracking of the neural correlates of specific haptic interactions and investigations of reparative plasticity in the sensorimotor cortex, with the aid of functional MR imaging (fMRI). In this paper, we present an fMRI compatible haptic interface with pneumatic actuation(More)
Wallerian degeneration (WD) is the process of demyelination and disintegration of the distal axonal segment following the interruption of the axonal integrity or damage to the neuron. We report a patient having WD of middle cerebellar peduncles due to pontine infarction caused by basilar artery thrombosis. We review the anatomy and discuss the pathogenesis(More)
In this work, we studied human head motions during upper extremity motor task, conducted in functional magnetic resonance imaging (fMRI) studies. The experiments were performed on a mock up of the MRI bench. Three kinds of linear movements in the caudal-cranial, left-right and anterior-posterior directions, a reaching movement as well as single joint(More)
Introduction Recovery of patients with spinal cord injury can only be successful, if patients are not immobile over a long time, because immobility results in a loss of neuronal function. In order to keep the patients mobile, new locomotor training devices (e.g. the LOKOMAT – a robotic gait orthosis manufactured by Hocoma AG, Switzerland) have been(More)
Reduced hindbrain herniation observed after intrauterine myelomeningocoele repair suggests that posterior fossa changes in myelomeningocoele are secondary results of prolonged prenatal spinal cerebrospinal fluid leak. Exceptionally, this transforaminal herniation results in 'degeneration' of cerebellar tissue, presumably due to mechanically induced(More)
Balo's disease also known as Balo's concentric sclerosis (BCS) is a rare demyelinating disorder which is characterized pathologically and radiologically by concentric rings of demyelinated and relatively myelin-preserved white matter. We describe the case of a 25-year-old female presenting with stroke-like symptoms who was diagnosed with BCS on MRI. At(More)
Little is known about the neural correlates underlying the control of highly coordinated bilateral lower limb movements. In this paper we present an fMRI paradigm consisting of balancing a virtual ball rolling on a virtual bar. The subject can control the position of the bar by its lower limbs using the MR-compatible stepper MARCOS. Concurrent visual and(More)
Bilateral thalamic glioma is one of the rarest tumor occurrences, representing a small fraction of thalamic gliomas, which only accounts for 1-1.5% of all brain tumors. It is usually a diffuse, low-grade astrocytoma (WHO grade II), seen mainly in adults, with approximately 25% of them involving children under the age of 15. Radiotherapy is the main mode of(More)
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM)(More)