Spinello Antinori

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Histoplasmosis is an endemic mycosis caused by a dimor-phic fungus with two distinct varieties pathogenic for humans: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. The latter is known to be restricted to sub-Saharan Africa, whereas the former is distributed worldwide. However, general textbooks of medical mycology when considering(More)
Candida species represent the fourth leading cause of nosocomial bloodstream infections (BSI) worldwide. However, candidaemia rates and species involved vary geographically. To evaluate the epidemiological pattern, risk factors for mortality and antifungal therapy of Candida BSI over a 5-year period (2008–2012) in a university hospital in northern Italy(More)
BACKGROUND This study aimed to provide a contemporary picture of the epidemiologic, clinical, microbiologic characteristics and in-hospital outcome of infective endocarditis (IE) observed in a single center in Italy. METHODS We performed a retrospective study of patients with definite or probable IE observed at the "L. Sacco" Hospital in Milan, Italy,(More)
OBJECTIVES A major side effect of antiretroviral drugs is nucleoside reverse transcriptase inhibitor (NRTI)-related mitochondrial toxicity, the in vivo diagnosis of which is difficult and not yet standardized. We used the [(13)C]methionine breath test to investigate hepatic mitochondrial oxidation in HIV-1-infected patients receiving antiretroviral therapy.(More)
Malaria is a vector-borne infection caused by unicellular parasite of the genus Plasmodium. Plasmodia are obligate intracellular parasites that are able to infect and replicate within the erythrocytes after a clinically silent replication phase in the liver. Four species (P.falciparum, P.malariae, P.ovale and P.vivax) are traditionally recognized as(More)