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Clickable Poly(ionic liquids): A Materials Platform for Transfection.
A post-polymerization click reaction is reported that provides facile access to trisaminocyclopropenium (TAC) ion-functionalized macromolecules of various architectures, which are the first class of polyelectrolytes that bear a formal charge on carbon.
Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging.
- Fanghao Hu, Spencer D. Brucks, T. Lambert, L. M. Campos, Wei Min
- ChemistryChemical communications
- 6 June 2017
A novel nanoparticle-based imaging strategy is introduced that couples biocompatible organic nanoparticles and stimulated Raman scattering (SRS) microscopy and the Raman-active polymer dots are nontoxic, rapidly enter various cell types, and are applied in multiplexed cell-type sorting.
The evolution of cyclopropenium ions into functional polyelectrolytes
The facile synthesis of a series of polymers and nanoparticles based on monomeric cyclopropenium building blocks incorporating various functional groups that affect physical properties are demonstrated, rendering this class of new materials as an attractive alternative to develop ion-conducting membranes.
Stereochemical Control Yields Mucin Mimetic Polymers
The development of synthetic mucin mimics that recapitulate the dense display of glycans and morphology of mucin underscore the significance of the extended mucin backbone for inhibiting virulence and highlight the importance of the polymer backbone in mucin surrogate design.
Functionalization of 3D covalent organic frameworks using monofunctional boronic acids
Fully charged: Maximizing the potential of cationic polyelectrolytes in applications ranging from membranes to gene delivery through rational design
This work focuses on cationic systems, and describes how various structural motifs influence macromolecular properties for anion exchange membranes and gene delivery vectors.
Synthesis of Robust Surface-Charged Nanoparticles Based on Cyclopropenium Ions
We investigate synthetic strategies of cationic surface-charged nanoparticles using cyclopropenium-based (CP) monomers and block copolyelectrolytes (BCPEs) via surfactant-free emulsion…
Impact of Electrostatic Interactions on the Self-Assembly of Charge-Neutral Block Copolyelectrolytes
The self-assembly of diblock copolymers (BCPs) comprising flexible polymer chains, driven by a balance of enthalpic and entropic forces, is well understood. If one of the blocks is a polyelectrolyt...
Cyclopropenium-Based Biodegradable Polymers
The synthesis and characterization of a series of novel biodegradable polymers bearing cationic cyclopropenium along a polyester backbone, either linear or cross-linked, are presented.
Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers
These studies highlight the importance of exercising precise control over polymer structure, both in terms of backbone identity and substituent nature, and the necessity of a robust, modular platform from which to study them.